NOVEL TECHNOLOGIES IN FORMULATIONS: AN OVERVIEW
Mohd Abdul Hadi1, Raghavendra Rao NG2*
1Dept of Pharmaceutics, Bhaskar Pharmacy College, Moinabad, R.R District, Hyderabad -500075, AP, India.
2Dept of Pharmaceutics, Jyothishmathi Institute of Pharmaceutical Science, Karimnagar - 505481, AP, India.
ABSTRACT
Significant advances have been attained in developing and
commercializing oral controlled release products. Many platforms are
available for delivering small molecule drugs with good aqueous
solubility in prolonged or delayed release forms. On the other hand, the
continuous improvement of current delivery technologies is also
important when it comes to decreasing cost and increasing efficiency.
Those advancements include novel excipient, processes, and
equipment as new tools formulation scientists can use to develop oral
controlled-release formulations. In the present review article, the novel
methods of preparing controlled or extended release formulations
which can be successfully used in chronotherapy have been mentioned.
These techniques also applied for drugs that require modification of
drug release, masking of bitter taste, and protection of volatile
substances. These technologies have also been found useful for timedrelease
dosage forms, as timing release tablets, time clock system and delayed-release tablets.
This article emphasis on the novel technologies such as capsule-in-a-capsule technology,
tablet-in-a-tablet technology and tablet-in-a-capsule technology.
Keywords: Oral controlled-release formulations, Chronotherapy, Capsule-in-a-capsule technology, tablet-in-a-tablet technology, tablet-in-a-capsule technology.
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