WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

MICROWAVE MEDIATED SYNTHESIS OF PHARMACOLOGICAL ACTIVE SUBSTITUTED DERIVATIVES OF 2-(4/-PHENOTHIAZINYL PYRAZOLYL) PYRROLES

Dr. Meghasham N. Narule, Dr. Mahesh K. Gaidhane, Dr. Pravin K. Gaidhane

ABSTRACT

Phenothiazines belong to an important class of heterocyclic compounds known for their pharmaceutical properties. Phenothiazine core is the active component in sedatives, tranquilizers, antituberculotics or bactericides. Phenothiazines are electron donor compounds with a low oxidation potential and they can form easily radical-cations.Lately phenothiazine has become very popular in material science or in biochemistry as marker for proteins and DNA. 2- [4/-hydroxyl benz-1/-(propene-1//-one)] Pyrrole (2) on treatment with primary amine gives 2-[biphenyl amine-1/-(propane-1//-one)] pyrrole (3) which react with sulphur and iodine affording substituted 2- [phenothiazinyl-8/-(propane-1//-one)] pyrrole (4a-j) which undergoes cyclization with NH2.NH2H2O and Substituted 2-(4/-phenothiazinyl pyrazolyl) pyrrole (5a-j) is obtained. The structure products were characterized by elemental analysis and spectral data.

Keywords: Pyrrole, Phenothiazinyl pyrazolyl, Pharmacological activity, Microwave method.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More