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Abstract

AN APPROACH FOR DESIGN AND CHARACTERIZATION OF NIOSOMES FOR CHLORPHENIRAMINE MALEATE

Vaishnavi. STP, K.Venkata Ramana Reddy, K.Sravani, Dr. B.Venkateswara Reddy

ABSTRACT

Niosomes are vesicles composed of non-ionic surfactants, relatively nontoxic, more stable and inexpensive, an alternative and superior to liposome will be acts as a target drug delivery system/CDDS. The aim of the present investigation was to formulate niosomes and subject to evaluation of particle size, entrapment efficiency and invitro studies and study concentration of drug towards size of niosomes. Niosomes were prepared by the thin film hydration method by various using combinations of cholesterol and spans with tweens as surfactants in different ratios and diethyl ethyl as a solvent with antihistamine drug chlorpheneramine maleate. Formulation containing span 20 was found to be 10.58 in micron diameter. Span 20(20 mg of drug) gained size of 13.73μ in diameter and span 20(12 mg of drug) has got less in particle size of 5.44 μ in diameter in comparison to span 60 of 14.41microns. The formulation of niosomes within combination of span 20 and cholesterol in 1:1 ratio has 93.8 % PDE and in combination of tween 60 and cholesterol in 1:1 ratio was 95.94 % PDE. The in vitro diffusion study suggests that higher entrapment efficiency was related with slow release comparatively. The in-vitro drug release of 68 %was found to be for the extended period of time of 12 hrs of optimized one. Niosomes prepared from combination of span 60 is a promising approach to improve the bioavailability of chlorpheneramine maleate as antihistamine even for an extended period of time which showed good physicochemical properties with controlled drug release pattern, thereby improving the bioavailability of the drug with minimization of side effects due to selective built up of drug concentration at site of action. The in-vitro diffusion study suggests that higher entrapment efficiency was related with slow release comparatively. The release pattern shown by these formulations were zero order and diffusion controlled mechanism.

Keywords: Niosomes, Chlorpheneramine maleate, Spans and Tweens concentrations, Cholesterol, in-vitro.


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