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Abstract

EVALUTION OF HEPATOPROTECTATIVE ACTIVITY OF TERMINELLA CATTAPA LEAVES ON PARACETAMOL-INDUCED HEPATOTOXICITY IN WISTAR RATS

Amna Ansari , S.M.Ghufran Saeed, Seema Ashraf, Nasreen Begum ,
Zafar Saeed Saify , Mehreen Asghar B. , S.Asad Sayeed

ABSTRACT

Purpose: Whole plant of Terminalia catappa has been used for the treatment of different diseases including cancer, skin infections, diabetes and liver disorder that prompted us to investigate the hepatoprotective effect of chloroform and methanol extract (CEIF and MEIF) of leave part of Terminalia catappa using paracetamol-induced liver damage in rats. Methods: The chloroform and methanolic extracts of Terminalia catappa (CEIF and MEIF) were studied for their hepatoprotective and antioxidant effects on paracetamol (750mg/kg) induced acute liver damage on Wistar albino rats. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin and total protein. Results: CEIF and MEIF at a dose level of 250mg/kg and 500mg/kg produce significant (P<0.05) hepato protection by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation, in a dose dependent manner. The effects of CEIF and MEIF were comparable to that of standard drug Silymarin. Conclusion: From this study, it can be concluded that the chloroform and methanol extract of hepatoprotective agent is not only an effective hepatoprotective agent, but also possesses significant (p<0.05) antioxidant activity.

Keywords: Terminalia catappa, hepatoprotective agent, Silymarin


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