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Abstract

IN-VITRO AND IN-VIVO FREE RADICAL SCAVENGING ACTIVITY OF AQUEOUS EXTRACTS OF SELECTED PLANT BARKS

G.V. Sampath Kumar, Dr.K.Eswar Kumar

ABSTRACT

The objective of this study is to find out the free radical scavenging
(antioxidant) activity of four different bark extracts namely Alstonia
scholaris, Ficus bengalensis, Pongamia pinnata and Ricinus
communis. The study includes both in-vitro methods and in-vivo
methods. The in-vitro free radical scavenging activity was recorded by
superoxide radical scavenging assay, hydroxyl radical scavenging
assay, hydrogen peroxide scavenging assay, nitric oxide scavenging
assay and DPPH method using various concentrations of different
extracts (12.5, 25, 50, 100, 200, 400μg/ml) against blank with ascorbic
acid as a standard of same concentrations. The in-vivo methods include
lipid peroxidation assay and reduced glutathione estimation. All the
extracts showed significant antioxidant activity when compared with the standard i.e.
ascorbic acid. The IC50 values of all the extracts were determined and tabulated. The
observed antioxidant activity of the selected plant barks might be due to the presence of
active constituents like flavonoids like quercetin and polyphenols, Saponins, vit. C, alkaloids
and sterols. Since reactive oxygen species are involved in stress and stress related disorders,
these plants may be beneficial in preventing the initiation or progression of such disorders.

Keywords: Alstonia scholaris, Ficus benghalensis, Pongamia pinnata , Ricinus communis, super oxide, DPPH reagent, glutathione, lipid peroxidation, Antioxidant activity, IC50


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