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            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

DEVELOPMENT AND EVALUATION OF A READY TO USE ANTIMALARIAL ORAL SUSPENSION

Harsha Kathpalia, Chetan Phadke

ABSTRACT

Some physiologically active agents such as antibiotics, anti malarial
are chemically unstable in water-based oral suspensions. Non-aqueous
suspensions can be produced which are extremely palatable, are readyto-
use, without any reconstitution and need not be refrigerated to
maintain the potency of the active ingredient and have a longer shelf
life relative to conventional dry syrup formulations. A ready-to-use
anhydrous suspension of a moisture sensitive antimalarial which can
be stored at room temperature was prepared and evaluated for its
organoleptic properties, sedimentation behavior, redispersibility,
moisture content, viscosity, accelerated physical and chemical stability.
The formulations showed improved redispersibility and no caking
tendency. The products exhibited longer shelf-life at ambient
conditions.

Keywords: Anhydrous vehicle, anti malarial, ready-to-use, stability, sweetener, thickener.


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