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Abstract

ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACT OF BACOLEPIS NERVOSA DECNE. EX. MOQ. USING CARRAGEENAN INDUCED PAW OEDEMA IN ALBINO RATS

Arockia Jenecius and Veerabahu Ramasamy Mohan*

ABSTRACT

The present study was conducted to evaluate the anti-inflammatory
activity in ethanol extracts of stem and leaves of Bacolepis nervosa.
The anti-inflammatory activity was assessed by carrageenan induced
paw oedema in albino rats. The stem and leaf extracts of this plant
were administered orally at doses of 150 and 300 mg / kg body weight
and the study was compared with a standard drug indomethacin (10 mg
/ kg). The highest dose of B. nervosa stem and leaf extracts (300 mg /
kg) produced a maximum inhibition of 82.28% and 79.64% at 3 hours
after administration respectively. The anti-inflammatory activity is
more effective in group V carrageenan induction with oral
administration of B. nervosa stem extract of 300 mg/kg body weight
compared to standard drug and leaf extract. Further and detailed studies are in progress for
the isolation of single entity responsible for anti-inflammatory activity and development of
suitable formulations.

Keywords: Carrageenan, Bacolepis nervosa, indomethacin, anti-inflammatory.


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