PREPARATION AND CHARACTERIZATION OF IBUPROFEN COCRYSTALS BY USING SOLVENT DROP GRINDING METHOD
Zalte Amar Gangadhar, Darekar Avinash Bhaskar, Gondkar Sheetal Bhaskar, Saudagar Ravindranath Bhanudas
ABSTRACT
Ibuprofen is a non-steroidal anti-inflammatory BCS class II drug of
low solubility and high permeability. Pharmaceutical cocrystals of
Ibuprofen were prepared with cocrystal formers, such as benzoic acid,
3-aminobenzoic acid, and cinnamic acid, to improve drug
solubility.Solvent drop grinding method was successful to make
Ibuprofen cocrystals. All new crystalline forms were characterized by
IR spectroscopy, differential scanning calorimetry, and X-ray
diffraction to confirm their purity and homogeneity. Cocrystals with
benzoic acid, 3-aminobenzoic acid and cinnamic acid showed a faster
powder dissolution rate than the reference active pharmaceutical ingredient (API). Cocrystals
of Ibuprofen with benzoic acid showed the highest solubility (7 times as compared with API)
while cocrystals with Ibuprofen and 3-aminobenzoic acid and cinnamic acid showed
comparably good solubility (3 times faster than the API) up to 60 min. The study showed
cocrystals is an emerging trend to modify physicochemical properties of drug to enhance
their pharmaceutical properties.
Keywords: Cocrystals, Cocrystallization, Ibuprofen, Grinding.
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