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Abstract

HYPOGLYCEMIC EFFECTS OF WHITE CABBAGE AND RED CABBAGE (BRASSICA OLERACEA) IN STZ INDUCED TYPE-2 DIABETES IN RATS

Alaa A. Gaafar*, Hanan F. Aly, Zeinab A. Salama, Naima Z.Mohamed

ABSTRACT

The present study aims to investigate the comparative potential and ameliorative effect of both white and red cabbages (Brassica oleracea) in the management of STZ induces diabetes in rats. Diabetes was induced in male Westar rats using streptozotocin; STZ, 60 mg/kg body weight. Diabetic rats showed significant elevation in serum total cholesterol (TC) , low density lipoprotein-Cholesterol (LDL-C) and triacylglycerol (TG) , while, significant decrease in serum high density lipoprotein –cholesterol (HDL-C) level. Oral supplementation of white and red cabbage extracts to diabetic rats resulted in insignificant change in serum total lipids level, TC, TG and HDL .LDL showed significant increase with white cabbagetreatment ,while, red cabbage demonstrated significant decrease as compared to normal control rats.Diabetic rats exhibited significant increase in liver function enzymes; alanine and aspartate aminotransferase (AST and ALT), alkaline phosphatase (ALP) and total bilirubin (TB) levels. Treatment of diabetic rats with white cabbage demonstrated significant increase in AST enzyme activity, while, insignificant change in AST was noticed with red cabbage extract. However, ALT enzyme activity recorded insignificant change with white and red cabbage extracts. White cabbage treated - diabetic rats demonstrated significant increase in ALP enzyme activity, although, diabetic rats treated with red cabbage declared insignificant change. Whereas TB level, showed insignificant change with both treatments. The present results reveal also, significant lower levels of total protein (TP) and albumin (ALB) in diabetic rat's .Treatment of diabetic rats with white and red cabbage extracts, showed insignificant change in TP and ALB levels. Blood glucose level of diabetic rats showed significantly increase. Treatment of diabetic rats with white and red cabbage extracts restored blood glucose level to normal value .In addition , diabetic rats recorded significant reduction in glutathione (GSH) content while, malondialdehyde (MDA) level showed significant elevation. However, diabetic -rats treated with white and red cabbage extracts exhibited insignificant change in GSH ,while significant increase in MDA levels .Significant increase in pro-inflammatory cytokines; tumor necrosis factor- α(TNF-α) and C- reactive protein (CRP), was detected also in diabetic rats .Treatment of diabetic-rats with both white, red cabbage extracts showed significant increase in TNF-α levels ,while, insignificant change was observed in CRP level. Moreover, diabetic status caused significantly elevated levels of serum total urea and creatinine. White and red cabbage extracts treated- diabetic rats showed, insignificant change in total urea and creatinine levels as compared to normal control rats. Histopathological investigation of diabetic rat's liver showed hydropic degeneration of hepatocytes and oval cells proliferation. Histopathological examination of diabetic kidney, demonstrated interstitial nephritis.However, pancreas of diabetic rats revealed necrosis of islets of Langerhan’s and inflammatory cells infiltration. Treatments of diabetic rats with white and red cabbage extracts declared amelioration in hepatic, renal as well as pancreas architectures and apparent normal .So, it could be concluded that, the antioxidant, antiinflammatory and anti-hyperglycemic properties of Brassica oleracea extracts may offer a potential therapeutic source for the treatment of diabetes.

Keywords: White cabbage, Red cabbage, Hypoglycemic Effects, antidiabetic.


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