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Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF SIMVASTATIN

M.Ravali , K.Navaneetha, B.Venkateswara Reddy, N.Karthik

ABSTRACT

The purpose of this study is to formulate a controlled release matrix tablet of simvastatin a drug which is used in the treatment of dyslipidemia. Simvastatin has a short biological half life of 3 hours which necessitates multiple daily dosing hence a controlled release formulation of simvastatin is developed. Controlled release tablets of simvastatin are prepared by direct compression method by using various polymers such as Eudragit RLPO and Eudragit RSPO. FTIR studies revealed that drug and the excipients used were compatible with each other. The precompression studies revealed that the powder blend has good flow properties, and the post compression studies shows that the results were within the limits. Matrix tablet of Simvastatin that contained a blend of drug and Eudragit RLPO in 1:1.5 showed 99.41% of drug release in a period of 24 hours. The drug release mechanisms for formulations were best described by Higuchi’s and Krosmeyer Peppas. The drug release of optimised formula followed non fickian type of diffusion. Thus, concluded that the control release matrix tablets prepared by using Eudragit RLPO were more promising than the Eudragit RLPO.

Keywords: Control Release; Simvastatin; Dyslipidemia; Eudragit RLPO; Eudragit RSPO; Non fickian Diffusion.


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