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Abstract

MICA NANOPARTICLES CAN BE AN ANTIODOTE FOR MALE GERM LINE: AN ULTRASTRUCTURAL EVALUATION IN WISTAR RATS

Babita Bhatia, Purushottam G Kale, Pramod Meshram

ABSTRACT

The mammalian testis is composed of male germ cells (the gametes) and supporting somatic cells that together promote a highly regulated series of developmental transitions in the seminiferous tubules of the testis to produce functional spermatozoa. Heat is known to cause deleterious effects on the male germ cell line. Mica nanoparticles (nanomica) are known to cure sexual debility, erectile dysfunction, impotency and azoospermia. Under the looming threat of global warming, the aim of the experiment was to substantiate that nanomica can be used as anti-impotency fecundity drug for people living under heat stress conditions. Thirty two male Wistar rats were divided into four groups. G1 acted as control, G2 comprised nanomica only treated group, G3 as heat treated group and G4 were given combined heat treatment and nanomica. The rats were euthanized on day 31 and a small part of the tissue was subjected to ultrastructural study. G1 rats showed normal progression of germ cell development with normal morphological characteristics. G2 rats showed total synchrony in generations of germ cells having normal morphological characteristics, presence of abundant secretory granules and lumen filled with large number of sperms. In G3 rats heat stress had caused degeneration of seminiferous tubules manifested in deleterious changes in somatic and germ cells, undulating basal membrane, apoptotic nucleus and vacuole formation. G4 rats revealed improvement in specific organization of spermatogenic cells, possession of normal morphological characteristics by germ cells, presence of bilayered basal lamina, well defined morphology of sperms and presence of normal Leydig cells. The results indicate that nanomica ameliorates non-proliferation of germinal epithelium by increasing the specific germ cell associations between developing and proliferating male germ cell line resulting in the formation of normal spermatozoa. Hence, nanomica can evidently be used to improve male reproductive health and to contribute to the therapeutic management of male infertility in heat stressed conditions.

Keywords: nanomica, azoospermia, fecundity, synchrony, apoptotic, therapeutic.


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