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Abstract

EVALUATION OF EFFECT OF ETHANOLIC EXTRACT OF PHYLLANTHUS DEBILIS ON ANTITUBERCULAR DRUGS INDUCED HEPATOTOXICITY IN WISTAR RATS

Anand Koppal, Praveen SE, Tara Shanbhag, Ankita Kushal, Don Mathew, Smita Shenoy, Navin Patil

ABSTRACT

Background: The whole plant of Phyllanthusdebilis has been shown to have hepatoprotective effect againstcarbon tetrachloride induced hepatotoxicity in rats. This study was undertaken to evaluate its effect on antitubercular drugs induced hepatotoxicity in rats. Methods:The study was conducted in five groupsof male wistar rats, each having six animals.Gum acacia and a combination of isoniazid,rifampin andpyrazinamide were administered to the two control groups. The ethanolic extract of the whole plant ofPhyllanthusdebilis was administered in a dose of 200 and 400 mg/kg to the two test groups, respectively. Silymarin (hepatoprotective, 50mg/kg, orally) was administeredto the fifth group.Serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, tissue malondialdehyde and thiols were estimated.Statistical analysis was done using one-way ANOVA followed by Tukey’s test. Results: The rise in levels of serum enzymes was lower in rats treated with a combination of antitubercular drugs and high dose (400 mg/kg) of ethanolic extract of P debilisas compared to those administered antituberculardrugs alone. Coadministration of high dose of extract of P debiliswithantitubercular drugssignificantly (p<0.05) decreased MDA levels and increased thiol levels.But the levels of these biochemical parameters were not normalized.Conclusion: Phyllanthusdebilis, in high dose, exerted a partial protective effect against antitubercular drugs induced hepatotoxicity in rats.

Keywords: Phyllanthusdebilis, isoniazid, rifampin, pyrazinamide, hepatoprotective.


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