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Abstract

FORMULATION, CHARACTERIZATION AND IN-VITRO EVALUATION FOR SOLUBILITY ENHANCEMENT OF A POORLY WATER SOLUBLE DRUG USING NANOEDGE TECHNIQUE

CVN Satyajit , ME Bhanoji Rao , Ch Niranjan Patro , Suryakant Swain ,
Sukesh Taria , and Sunil Kumar

ABSTRACT

The purpose of the present investigation was to increase the solubility and dissolution rate of Clopidogrel bisulphate by the preparation of nanosuspension by precipitation with High-pressure homogenization (HPH) i.e. Nanoedge technique. Clopidogrel bisulphate (CPS) is a crystalline poorly water soluble drug having fair bioavailability of 50%. In this present work different batches were fabricated using different polymers such as PVP K-30 and PVA with different surfactants such as SLS and Tween 80. Preformulation study was carried out different techniques such as FTIR and differential scanning calorimetry (DSC). Prepared nanosuspension was evaluated for its particle size using scanning electron microscopy (SEM), Zeta- potential, in-vitro dissolution study and short term stability study was done for the drug profile. The results showed that nanosuspension prepared with polymer PVP K-30 and surfactant sodium lauryl sulfate (SLS) proved to be better optimized batch compared to the available marketed product. This can be explained due to greater surface area of the nanosuspension compared to the conventional techniques.

Keywords: Clopidogrel bisulphate, Nanosuspension, HPH, Zeta-potential, SEM, DSC.


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