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Abstract

IN VITRO STUDY OF THE EFFECT OF CORN SILK ON GLUCOSE UPTAKE BY ISOLATED RAT HEMI-DIAPHRAGM

Ghada. M , Eltohami M.S,Adurahman H. N, Mahmoud M. E. Mudawi

ABSTRACT

the present study the methanolic extract of corn silk was evaluated
for antidiabetic activity. The antidiabetic activity was studied using the
glucose uptake by isolated rat hemi-diaphragm using in-vitro model.
Corn silk increased the uptake of glucose by isolated rat hemidiaphragm
significantly (P<0.001) and was found to be more effective
than insulin. It appears that corn silk has direct peripheral action on
glucose uptake. The value of glucose uptake by rat hemi-diaphragm
after addition of corn silk extract was 109±1 as compared to control
(12± 1) and Insulin (49 ± 8)mg/g/30min .These results strongly suggest
that Corn silk will be alternative choice for the treatment of diabetes
mellitus.

Keywords: Anti-diabetic, Rat hemi-diaphragm, corn silk, Glucose uptake.


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