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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF UNIT MOULDED SEMISOLID JELLY FOR ORAL ADMINISTRATION AS A CALCIUM SUPPLEMENT

Tanu Godhwani1, Mahavir Chhajed2*, Atika Chhajed3, Deepshikha Tiwari1

1Modern Institute of Pharmaceutical Sciences, Gram Alwasa, Behind Rewati Range, Sanwer Road, Indore (M.P.)
2SAFE Institute of Pharmacy, Gram Kanadiya, Indore (M.P.)
3Devi Ahilya College of Pharmacy, Jaora Compound, Chhawani, Indore (M.P.)

ABSTRACT

The present study was conducted with an aim to formulate and evaluate the unit molded jelly containing calcium supplement and optimization of this dosage form which will dissolve slowly when kept in contact with mouth without any irritation or inflammation and bitter after taste. The oral route of administration is the preferred route of drug delivery. Now-a-days, jelly candies have become very common in children as they enjoy chewing the jelly. The formulation of jelly is advantageous for drug delivery in paediatric patients and may also be used in the cases where tablet or capsule swallowing is difficult. The jellies were evaluated for their physiochemical parameters like Color, taste loss on drying, pH, spreadability, test for presence of heavy metals and stability studies. All the ten formulation (F1 to F10) under study was found to be stable and showed comparable appearance, pH, spreadability and viscosity. The article describes about the formulation aspect of jelly, excipients and flavors employed and the evaluation parameters along with the drug used in the formulation. The optimized formulation F4 was found to be stable for the period of 3 months as per ICH guidelines.

Keywords: Jelly formulation, calcium supplements, unit molded dosage, physiochemical parameters.


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