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Abstract

METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF OFLOXACIN AND DEXAMETHASONE SODIUM PHOSPHATE BY RP-HPLC

G.N.Renukadevi*, M.Sri lakshmi, V.Prathyusha, SK.Sharmila, K.Shantha Kumari

ABSTRACT

A new simple isocratic analytical method has been developed and validated for estimation of Ofloxacin and Dexamethasone sodium phosphate was carried out on Agilent CN, 250mm x 4.6mm, 5μm column in isocratic mode using mobile phase composition of Acetic acid Buffer : Acetonitrile (70 : 30% v/v) with flow rate of 1.0 ml /min at 241 nm. The linearity of the method was demonstrated over the concentration range of 6-180 μg/ml for ofloxacin and 2-60 μg/ml for Dexamethasone sodium phosphate with correlation coefficient of 0.999 & 0.999 respectively. The developed method was validated as per ICH guidelines. The amounts of both the drugs were found to be in good agreement with label claim. The developed method was validated for precision, accuracy, sensitivity, robustness and ruggedness. Hence, this method is used for routine analysis of titled drugs in combination of tablet formulation.

Keywords: Ofloxacin and Dexamethasone sodium phosphate, RP-HPLC, Validation


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