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Abstract

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 2- (DIALKYLAMINO)-N-(5-(5-(ALKYLTHIO)-1, 3,4-OXADIAZOL-2- YL)BENZOXAZOL-2-YL) ACETAMIDES

Nageshwara Rao Chilumula, Blessi Priyanka K*, Ravi J*, Kusuma B,Kalyani T., Gade Dayakar

ABSTRACT

A series of 2-(dialkylamino)-n-(5-(5-(alkylthio)-1, 3, 4-oxadiazol-2- yl) benzoxazol-2-yl) acetamides were synthesized by taking 4- carbomethoxyphenol a starting material.The final resultant compounds were evaluated for antimicrobial activity by using disc fusion method. All E.coli and S.typhi ,B.subtilis and S.aureaus and A.niger and C.albicans were adopted as Gram negative, Gram positive and fungal organisms. Among all the compounds of 2-(dialkylamino)-N-(5-(5- (alkylthio)-1, 3, 4-oxadiazol-2-yl) benzoxazol-2-yl) acetamides (XV),compound XVd was active against both Gram positive B.subtilis and S.aureaus and Gram negative bacteria E.coli and S.typhi. Compound XVd, XVk and XVp were active against the organisms A.niger and C.albicans

Keywords: Oxadiazole, Benzoxazole, antibacterial, antifungal


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