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Abstract

EVALUATION OF SOY LECITHIN AS A DIRECT COMPRESSION VEHICLE AND SUBSTITUTE OF LUBRICANT IN DICLOFENAC SODIUM TABLETS

R.E.Ugandar*, J. Sarah, Kiran.C.Nilugal, Dr. Nagarajan Srinivasan, Dr.Nagashekhara Molugulu, Asif Iqbal Chittur

ABSTRACT

In the current study soy lecithin powder was evaluated as a direct compression vehicle (DCV) and as a substitute of lubricant in the manufacture of directly compressed diclofenac sodium tablets. In the study two formulations, F1 and F2 of diclofenac sodium were prepared by direct compression method. F1 was prepared with the blend of drug, MCC and magnesium stearate where as F2 was prepared with the blend of drug, soy lecithin powder and a small proportion of MCC. The prepared formulation blends were subjected to pre-compression studies such as; angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The blends were subjected for direct compression. The prepared tablets of F1 and F2 were subjected to post compression studies like weight variation, hardness, friability, disintegration and dissolution. From the data the drug release profile from F1 and F2 were studied. The results of F1 are compared with obtained results F2. On comparison the pre-compression parameters of F2 were nearly same as those of F1 and the post compression parameters were found to be slightly better than those of F1 by resulting in slightly better release of the drug. The study revealed that soy lecithin could both as a direct compression vehicle and lubricant in tablets and shown enhanced bioavailability of the drug during in-vitro dissolution studyfunction

Keywords: Soy Lecithin, Direct Compression Vehicle, Lubricant, enhanced bioavailability.


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