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Abstract

SIMULTANEOUS ESTIMATION OF LOPERAMIDE HYDROCHLORIDE AND NORFLOXACIN BY VALIDATED UVSPECTROPHOTOMETRIC METHOD

Sharma Ravi*, Kaur Amandeep

ABSTRACT

A simple, accurate, precise and reproducible spectrophotometric method has been developed and validated for the simultaneous estimation of Loperamide hydrochloride and Norfloxacin in combined capsule dosage form by Q-Absorbance ratio method. Q-Absorbance ratio method involves two wavelengths; the iso-absorptive point and λmax of loperamide hydrochloride i.e. 231.5 nm and 222 nm respectively in methanol. The linearity was detected in the range of 5- 35 μg/ml (R2 = 0.999) for Loperamide hydrochloride and 1-7 μg/ml (R2 = 0.998) for Norfloxacin. The accuracy existed between 98-102% and the %RSD was less than 2%. The developed method was validated for linearity, accuracy and precision as per ICH guidelines.

Keywords: Loperamide hydrochloride, Norfloxacin, Q-Absorbance ratio method


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