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Abstract

FORMULATION AND EVALUATION OF FIXED DOSE COMBINATION PRODUCTS OF ANTITUBERCULAR DRUG

Shital Shantaram Patil*, Poonam A. Salunke, Rupali S. Wagh, Dr. S.D. Barhate

ABSTRACT

Objective of the present study is to formulate and evaluate fixed dose combination tablets of Rifampicin and Isoniazid. The granules of Rifampicin and Isoniazid were prepared separately by wet granulation, then lubricated blend was compressed using tablet compression machine by setting the machine speed in the range 12- 28 RPM with desired processing parameters such as average weight, uniformity of weight, thickness, hardness & friability. These tablets were evaluated for the various physical parameters like appearance, weight variation, hardness, friability and disintegration. Coating was done in Ganscoater coating pan in two lots. Dissolution studies FDC tablets were performed along with uncoated and film coated tablets separately. The cumulative percentage drug release for coated tablet was found to be around 96%. From in vitro studies it was concluded that the prepared tablet gives more satisfactory results and patient compliance.

Keywords: Rifampicin, Isoniazid, Film coating, fixed dose combination products, Ganscoater, tuberculosis.


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