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Abstract

EFFICACY OF CONVOLVULUS MICROPHYLLUS ROOT EXTRACTS IN REVERSING CARBOFURAN INDUCED OVARIAN ANOMALIES IN CLARIAS BATRACHUS (Linn): AN ULTRA STRUCTURAL STUDY

Prakriti Verma and G. B. Chand*

ABSTRACT

The impact of aqueous extract of Convolvulus microphyllus root (CMR) was investigated against carbofuran induced ovarian atrophy in fresh water air breathing fish Clarias batrachus. Fishes were exposed to 1.5 mg L-1 of carbofuran for 1, 2 and 4 weeks respectively. These fishes were further treated with aqueous extract of CMR for a period of 30 days @ 50 mg kg-1 body weight daily orally by gastric intubation. The T3 (Triiodothrionine), T4 (Tetra iodo thrionine) and TSH (Thyroid stimulating hormone) in blood serum were assayed. The histopathological examination of ovarian tissues was done on light microscopy and transmission electron microscopy. The serum level of T3, T4 and TSH showed a significant elevation of carbofuran treated fish when compared with control. They showed a significant recovery after CMR treatment for 20 days. Concomitant treatment of carbofuran and CMR to the experimental group showed non significant (at P<0.05) changes in serum T3,T4 and TSH .The CMR treatment alone to control group didn‟t show any significant correction in elevated serum T3,T4 & TSH. The histopathological examination of ovarian tissues of corresponding groups showed a sign of retrieving towards normalcy. A perfect co-relation between hormone level and histopathology reveals the ameliorating activity of CMR against carbofuran induced ovarian anomalies in fish.

Keywords: Carbofuran,T3, T4 ,TSH, Clarias batrachus, Convolvulus microphyllus


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