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Abstract

GASTRO-RETENTIVE FLOATING DRUG DELIVERY SYSTEM CONTAINING ANTIHYPERTENSIVE DRUG – AN OVERVIEW

Ghorpade Prafull* Kamble Shrenik 

ABSTRACT

The purpose of writing this review on gastro retentive floating drug delivery system was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. Hypertension is one of the world‟s major diseases.It currently affects an estimated143 million people worldwide and the number is growing rapidly. Research is directed towards overcoming physiological adversities such as short gastric residence time (GRT) & unpredictable gastric emptying time (GET). These systems will be very much useful to deliver „narrow absorption window‟ drugs. Four technologies have involved a substantial number of human clinical trials: floating, mucoadhesion, density modification, and expansion. The floating drug delivery system can remain in the gastric region for several hours via float on the gastric contents and hence significantly prolong the gastric residence time of drugs.In the recent years, scientific and technological advancement have been made in the research and developed of novel drug delivery system. By overcoming physiological troubles such as short gastric residence time and unpredictable gastric emptying times, oral route is the most preferable route of administration but it has certain limitation for those drugs which absorb from upper part of GI tract or having narrow absorption window. The bioavailability of these drugs by increasing the residence of the dosage form in the stomach. The gastric residence time of the dosage form can be improved by formulating them as floating drug delivery system. The current and recent development of stomach specific antihypertensive drug formulated as floating drug delivery system is discussed in this review.

Keywords: residence time, floating drug delivery system, Antihypertensive drugs, narrow absorption window.


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