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Abstract

ORODISPERSIBLE FILM DOSAGE FORM: A REVIEW

Dnyaneshwar H.R*., Wale K.K., Sayyed S.F., Dr. Chaudhari S.R.

ABSTRACT

Orodispersible dosage forms are promising new approaches for drug delivery. They enable an easy application, as there is no need to drink high amounts of liquids or swallow large solid dosage forms. The aim of the study was to develop an orodispersible film (ODF) as an alternative to tablets, syrups or suppositories for the treatment of vomiting and nausea, especially for the pediatric population. Oral thin film, a new drug delivery system for the oral delivery of the drugs, was developed based on the technology of the transdermal patch. Fastdissolving oral thin film is a solid dosage form, which disintegrate or dissolve within 1 min when placed in the mouth without drinking of water or chewing. Oral film includes various ingredients forits formulation which includes polymers, active pharmaceutical ingredient, film stabilizing agents, sweeteners, flavours, colors, saliva stimulating agents, preservatives, surfactants etc but the first and far most a very essential ingredient which helps in film formation is a Polymer. Fast dissolving Film is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity, delivering the drug to the systemic circulation via dissolution when contact with liquid is made. Water-soluble polymers are used as film formers for fast dissolving films. The water-soluble polymers achieve rapid disintegration, good mouth feel and mechanical properties to the films. Fast-dissolving oral thin film offer fast, accurate dosing in a safe, efficacious format that is convenient and portable, without the need for water or measuring devices. In this review article the different polymers used for preparation of fastdissolving oral thin film like Pullulan, Gelatin, Sodium Alginate, Pectin, Rosin, Starch, Chitosan are discussed together with th physicochemical properties and film forming properties.

Keywords: Fast dissolving films, Oral thin films, ODF.orally disintegrating dosage form


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