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Abstract

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL STUDIES OF BIOLOGICALLY ACTIVE BENZOTHIAZOLE DERIVATIVES

*D.Maruthamuthu, Dr. (Mrs.) P.Shameela Rajam, Dr. (Mrs.) P. Christina Ruby Stella,
R.Ranjith

ABSTRACT

A series of some benzothiazole was synthesized and evaluated for antimicrobial activity. The reaction of aniline compounds with ammonium thiocyante and HCl yielded 1 phenylthiourea. The title compounds were synthesized by treating 1-phenylthiourea with bromine in glacial acetic acid. Their structures were confirmed by IR,1H-NMR and 13C-NMR spectral techniques. Docking study was done to find the binding capacity of the synthesized compounds with the protein molecule COX-2

Keywords: Benzothiazole, pharmacological activity, Docking


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