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Abstract

HEPATOPROTECTIVE ACTIVITY OF AQUEOUS BARK EXTRACT OF ALSTONIA SCHOLARIS IN PARACETAMOL AND ETHANOL INDUCED LIVER DAMAGE IN ALBINO WISTAR RATS

G.V.Sampath Kumar*, Santosh Kumar Ranajit, Dr.K.Eswar Kumar

ABSTRACT

The In vivo hepatoprotective effect of aqueous extract of Alstonia
scholaris (AEAS) bark was evaluated in male rats against ethanol and
paracetamol induced liver damage in preventive and curative models.
Liver injury was induced by 40% ethanol administration (3.7 g/kg bw,
orally) for 28 days and in the other case hepatic damage was induced
by the administration of Paracetamol at a dose of 2g/kg bw for 11 days.
In two different sets of experiments, the AEAS extracts (100, 200 and
400 mg/kg bw) and silymarin (100 mg/kg bw) were administered
orally in preventive and curative models. Ethanol administration as
well as Paracetamol administration caused severe hepatic damage in
rats as evidenced by elevated serum aspartate aminotransferase (AST),
alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total
bilirubin levels. The AEAS and silymarin administration prevented the toxic effect of ethanol
and Paracetamol on the above serum parameters in both preventive and curative models. The
present study concludes that aqueous extract of Alstonia scholaris bark showed significant
hepatoprotective activity against ethanol induced hepatotoxicity as well as Paracetamol
induced hepatotoxicity.

Keywords: Alstonia scholaris; Ethanol; Paracetamol; Hepatoprotective; Silymarin


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