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Abstract

PHYTOCHEMICAL SCREENING AND STUDIES ON THE EFFECTS OF ORAL ADMINISTRATION OF PALM WINE EXTRACT OF DATURA STRAMONIUM ON THE ACTIVITY OF TISSUE ENZYMES AND HISTOPATHOLOGY OF ALBINO RATS.

Sanni, M., Ejembi, D. O., Abbah, O. C., Olajide, J.E, Ayeni, G., Usman, S.S., and Salifu, M.

ABSTRACT

Phytochemical screening and the effects of oral administration of palm
wine extract of Datura stramonium on the activity of tissue enzymes
and histopathology of rats was investigated. Forty (40) experimental
rats of average weight of 100-150g were divided into four groups; A,
B, C, and D comprises ten (10) rats each. Subgroups A, B, and C were
administered with varying concentrations of palm wine extract of
Datura stramonium, and group D served as the control group. The
animals were kept in separate metabolic cages and fed with rat chow
with water provided ad libitum. Rats in each group (A, B, C) where
given 0.5ml/ kg body weight of the extract per day and sacrificed after
day 7, 14, and 21. Rats in the control group (D) were given 0.5ml/ kg body weight of fresh
palm wine daily. The enzyme activities acid phosphatase (ACP), aspartate amino transferase
(AST) and alanine amino transferase (ALT) were measured. The serum total protein was
measured using Biuret method. Histological analysis was carried out on the tissues (kidney,
liver and intestine). A significant increase (p<0.05) in the activity of the enzyme (ACP, ALT
and AST) and a significant decrease (p<0.05) in total serum protein were observed. Tissue
biopsy showed a clear evidence of cell erosion in the treated groups, which was not apparent
in the control group.

Keywords: Datura stramonium, ACP, AST, ALT.


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