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Abstract

GREEN SYNTHESIS OF NANOSILVER AND ITS EFFECT ON PHASE SOLUBILITY OF FEW BCS CLASS II DRUGS

Dr. Ajit Shankarrao Kulkarni*, Mr. Kailas Madhukar Karande, Dr. Nagesh Hanumantrao Aloorkar, Mr. Jayprakash Sitaram Suryavanshi,

ABSTRACT

Nanometals are developing tools for drug delivery systems owing to
their unique properties viz. surface plasmon resonance, high surface to
volume ratio, ability to interact not only with biomolecules but also
drug molecules, precise therapeutic targeting etc. These core properties
pertaining to drug delivery make them potential tool in pharmaceutical
research.In present investigation, silver nanoparticles were synthesized
using bioexcreta, cow urine and gelatin as stabilizing agent.
Synthesized nanosilvers were characterized by absorption
spectroscopy, infrared spectroscopy, transmission electron
spectroscopy and XRD. Absorption spectroscopy revealed successful
synthesis of nanosilver. Fourier transform infrared spectroscopy
showed contribution of functional groups stabilizing nanosilver. TEM depicted spherical
uniform size and shape of nanosilver. XRD study revealed face centered cubic crystals. These
nonfunctionalized nanosilvers were subsequently evaluated for acute toxicity study and found
safe. Studies were also extended to confirm effect of synthesized NS on phase solubility of
simvastatin and atorvastatin, and revealed appreciable increase in solubility of these drugs.
Present investigations suggest that a green method can be used to synthesize NS which is
ecological, economical, and time efficient. Further, NS could enhance solubility of
simvastatin and atorvastatin.

Keywords: Silver Nanoparticles, Green synthesis, Simvastatin, Atorvastatin.


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