WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF FLOATING TABLET OF CAPTOPRIL

Sameer Singh1, A K Pathak1, Neelima Goswami2*

1Department of Pharmacy Barkatullah University Bhopal (M.P) India.
2Sagar Institute of Research & Technology – Pharmacy Bhopal (M.P) India.

ABSTRACT

Present investigation highlights the effectiveness of floating tablets of Captopril formulated using different grades of hydropropylrmethylecellulose. Lactose and citric acid were utilized in different concentration as a channeling and chelating agent to obtain best optimized formulation. Formulations were optimized on the basis of floating lag time and in vitro drug release. Study revealed that channeling and chelating agent had significant effect on the release of the drug from floating hydrophilic matrix tablet. Three different viscosity grades of hydropropylrmethylcellulose namely K100M, K 15M and K 4M were used as a floating polymer or intention of polymer. It was observed that different viscosities not only influenced the drug release from hydrophilic matrix but they also affected the floating properties of the tablets. Dissolution profiles were subjected to various kinetic treatments to analyze the release pattern of the drug and it was found that drug released from diffusion mechanism and followed Higuchi’s kinetics. The in vitro drug release profiles of drug from all the plots showed high linearity (r2= 0.9813 to 0.9954). Optimized formulations were again subjected for thickness, friability, hardness, uniformity of content, uniformity of weight, in vitro dissolution. floating lag time, floating time and stability studies. Based on the results it can be concluded that the floating formulation of Captopril can be deployed to achieve better therapeutic effect through site specific delivery for effective period of time. Moreover it may also be utilized to increase the bioavailability of the drug which in turn can reduce the dose size.

Keywords: floating tablet, HPMC, MCC, Lactose, captopril.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More