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Abstract

EFFICIENT SCALABLE APPROACH FOR CLOPIDOGREL BISULFATE THROUGH PREFERENTIAL CRYSTALLIZATION OF(±)-2-(2-CHLOROPHENYL)-(6,7-DIHYDRO-4HTHIENO[ 3,2,C]PYRIDINE-5-YL-ACETAMIDE.

M. M. V. Ramana* and Rajesh K. Rao.

ABSTRACT

The present work deals with the efficient synthesis of Clopidogrel Bisulfate (Generic name : Plavix by Sanofi) through resolution of an important precursor (±) -2-(2-chlorophenyl)-(6,7-dihydro-4Hthieno[ 3,2,c]pyridine-5-yl-acetamide by preferential crystallization. This compound was synthesized in its racemic form as per the known process and was resolved by preferential crystallization. These efforts led to a successful isolation of enantiomerically pure isomers of (±)-2- (2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2,c]pyridine-5-ylacetamide.

Keywords: Clopidogrel Bisulfate, Preferential Crystallization, Racemic compound, Conglomerate, Racemization.


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