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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF SUBSTITUTED BENZOXAZOLE DERIVATIVES

*D.Maruthamuthu, Shameela Rajam, Christina Ruby Stella, Ranjith, Rajakumar

ABSTRACT

A Series of some novel benzoxazole compounds were synthesized and evaluated for anti-microbial activity. The reaction of o-aminophenol with dicarboxylic acid yield substituted benzoxazole. The title compounds were synthesized by treating substituted benzoxazole with oxalic acid,cinnamicacid, succinic acid,phthalic acid,salicylic acid.Their structures were confirmed by IR, 1HNMR, and 13CNMR. Anti-microbial activity against staphylococclus aureus was studied for the synthesized compounds.

Keywords: Benzoxazole, o-aminophenol, dicarboxylic acid, Antimicrobial.


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