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Abstract

IN SILICO AND IN VITRO EXPLORATION OF ANTIINFLAMMATORY ACTIVITY OF ENTADA PURSAETHA BY MOLECULAR DOCKING STUDIES

Narasimharao Bhogireddy, Pardhasaradhi Mathi, Nagavamsikrishna Ambatipudi,
Venkata Raman Bokka*

ABSTRACT

Back ground: Cyclooxygenase (COX), the key enzyme inside the conversion process involving arachidonic acid to prostaglandins which was involved in the pain prone process in living vertebrates. Cyclooxygenase isoforms are already identified and therefore are called COX-1 in addition to COX-2. Beneath a lot of situation, the actual COX-1 enzyme is usually developed constitutively (i.e., gastric mucosa) in contrast to COX-2 is usually inducible (i.e., sites of inflammation). Drug treatments, similar to aspirin, which hinder cyclooxygenase task, are already obtainable in much more towards the general public for approximately 100 years. A single key aim with this is usually to lay out a good anti-inflammatory molecule having a larger restorative window. This article explores the medicinal values of the Entada pursaetha which is having strong anti-inflammatory and analgesic properties. Materials and methods: Compounds were identified by GC-MS analysis through conventional extraction procedures. Identified lead compound structures were sketched by using chemsketch and marvinsketch software’s. An In silico study has been carried out by using the software Schrödinger maestro. Results and Discussion: The compound oleoyl chloride was found to have great anti-inflammatory action [~ 80 % thanstandard: Diclofenac]. The interactions of the isolated compounds has been proposed based on the docking studies.

Keywords: Cyclooxygenase, GC-MS, Schrödinger, anti-inflammation


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