WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

CHARACTERIZATION OF GUM FROM SESAMUM INDICUM LEAVES AS A SUSPENDING AGENT IN A PEDIATRIC PHARMACEUTICAL SUSPENSION

*Ndidi C. Ngwuluka1, Munirat Akanbi1, Inalegwu Agboyo1 and Onyinye J. Uwaezuoke2

1Department of Pharmaceutics and Industrial Pharmacy, Faulty of Pharmaceutical Sciences, University of Jos, Jos, Nigeria.
2Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Ago-Iwoye, Nigeria.

ABSTRACT

Studies are undertaken to develop excipients from plant resources due to their availability, low toxicity and biodegradability. In this study, a novel excipient, was extracted from the leaves of Sesamum indicum; rheology, structural elucidation by FTIR and phytochemical analysis were undertaken. Its suspending properties were determined by employing techniques such as sedimentation volume, viscosity, ease of redispersibility, and buffering in comparison with acacia and mainly tragacanth. The percentage yield of the gum was 1.96% with residual moisture of 5.6%. A quantity (0.25g) with relative viscosity of 5.2 of sesamum gum can be used to achieve a sedimentation volume, 10mL on the 14th day with ease of redispersibility of 12- 14secs. In summary, sesamum gum exhibited the potential to produce acceptable suspensions with quick restoration of homogeneity and no formation of aggregates. Furthermore, buffering further stabilized the viscosities of the suspensions. Hence, sesamum gum is a potential pharmaceutical excipient for pharmaceutical suspensions that is accessible, cost effective and environmental friendly.

Keywords: Sesamum, suspending agent, excipients, natural gums, pharmaceutical, suspensions.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More