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Abstract

UV-SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF AZILSARTAN MEDOXOMIL IN PHARMACEUTICAL DOSAGE FORM.

Smita S.Aher*, Dr.RB.Saudagar

ABSTRACT

In the present research work simple, accurate, precise Area under curve method have been developed and Validate for Azilsartan Medoxomil in Active Pharmaceutical Dosage form Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension. U.S. Food and Drug Administration (FDA) approved Azilsartan Medoxomil for the treatment of high blood pressure in adults. This method involves calculation of integrated value absorbance with respect to wave lengths of 239nm and 259 nm respectivelyan absorption maximum was found to be at 249 nm with the solvent system methanol. The drug follows Beer law in the range of 4-14 μg/ml with correlation coefficient of 0.989. The percentage recovery of Azilsartan Medoxomil ranged from 99.9 to 100.3 % in pharmaceutical dosage form.The developed methods are validated according to ICH guidelines. Hence these methods can be used for the routine analysis of Azilsartan Medoxomil in bulk and tablet dosage form.

Keywords: Azilsartan Medoxomil(AZM),Area under the Curve (AUC) Method, Validation.


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