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Abstract

DESIGNING AND CHARACTERIZATION OF ATENOLOL FAST DISSOLVING ORODISPERSIBLE FILMS USING DIFFERENT POLYMERS

Amit B. Patil*, R. Narayana Charyulu

ABSTRACT

The present research was undertaken with the objective to evaluate the film forming properties of pullulan, hydroxyypropyl methyl cellulose 15cps (HPMC) and poly vinyl alcohol in formulating fast dissolving orodispersible films (FDOF) of atenolol.Solvent casting technique was employed to formulate atenolol FDOF. Glycerin and aspartame was used as plasticizer and sweetening agent.The optimum concentration of plasticizer, polymer and solubilizing agent were developed through morphological characterization such as deformation caused during removing from die cavity, surface stickiness and transparency. The physiological evaluation such as thickness, weight variation, disintegration time, in vitro dissolution, drug-excipient studies was also performed.Atenolol FDOF showed optimum thickness, drug content and folding endurance. The disintegration time of formulation PU3 film was found to be 13 sec with in vitro drug release of 98.01 % in 105 sec, which was better than other prepared formulations. Drug-excipients interaction studies performed using FTIR; showed no interaction. Surface pH was found to be neutral, indicating safety of administration. Atenolol FDOF formulated using pullulan and PVA showed complete transparency with smooth surface.Thus based on the results of the present research it can be concluded that polymer pullulan showed optimum characteristics as a film forming polymer for atenolol FDOF when compared to HPMC 15cps and PVA.

Keywords: Fast dissolving films, atenolol, pullulan, solubilizing agent.


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