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Abstract

FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF RIZTRATRIPTAN

Sandeep Aher*, Dr. Salunkhe K. S., Dr. Chaudhari S. R, Prin. and Dr. Aher A.B

ABSTRACT

Rizatriptan benzoate is a potent and selective 5-HTIB/ID receptor agonist and is effective for the treatment of acute migraine. Sublingual formulation has the advantage of offering fast relief from migraine due to faster drug delivery. The present study involves the formulation and evaluation of fast disintegrating sublingual tablets of rizatriptan benzoate to produce intended effects. The sublingual rizatriptan benzoate tablets were prepared by the method of direct compression. The superdisintegrants used were cross carmellose sodium and cross povidone. The powder flow properties of all formulations were evaluated for diameter, thickness, weight variation, hardness, friability, wetting time, water absorption ratio, drug content, in vitro and in vivo disintegration time as well as in vitro release and were found to be satisfactory. The optimised formulation containing cross povidone disintegrated very fast and invitro drug release was very high.

Keywords: Rizatriptan benzoate, Sublingual Tablet, In vitro drug release.


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