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Abstract

FORMULATION AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDROCHLORIDE

*Javed A.Mirza, Dr. A.P.Pingle, Nanasaheb Kale, Mayur Gandhi, Sandesh More,Govind Dhongale

ABSTRACT

Objective of the present study is to formulate and evaluate the matrix tablets of Metformin hydrochloride. Formulations were designed by using 32 Factorial designs and a total of nine formulations were prepared (F1-F9). Preformulation tests were performed for identification of drug and characterization of polymers. Blend of powders of respective formulations were evaluated for Bulk density, tapped density, Hausner’s ratio, Carr’s Compressibility index, Angle of repose. Tablets were prepared by direct compression method and evaluated for thickness, hardness, friability, weight variations and drug content. Dissolution studies were performed and percent cumulative release was found to be satisfactory with 93.14% and formulation was found to be stable at 400C±20C and 75% RH.

Keywords: Metformin Hydrochloride, Matrix tablet, type 2 Diabetes mellitus, Factorial design.


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