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Abstract

FORMULATION AND EVALUATION OF FAMOTIDINE FAST DISSOLVING ORAL FILM

S H Sonawane*, V.V.Patil V. M. Thakare, B. W. Tekade, Dr.V R Patil

TVESíS Honíble Madhukarrao Chaudhari College of Pharmacy, Faizpur

ABSTRACT

Over the recent past, many of the research groups are focusing their research on Fast Dissolving Dosage Form technology. However, some patients, particularly paediatric and geriatric patients, have difficulty in swallowing or chewing solid dosage forms or unwilling to take these solid preparations due to fear of choking. The main advantages of FDOFís are towards paediatric and geriatric patient population where the difficulty of swallowing larger oral dose is a main problem. This technology has been used for local action, rapid release products and for buccoadhesive systems that are retained for longer period in the oral cavity to release drug in controlled fashion. FDOF offers an alternate platform for molecules that undergo first pass metabolism and for delivery of peptides. The aim of this study was to develop an innovative fast dissolving oral film (FDOF) of Famotidine. . The new dosage form was obtained by solvent casting method using polymers such as Hydroxy Propyl Methyl Cellulose, and Polyethylene Glycol. A various concentration of polymers were conducted in order to optimize API concentration of the new dosage form. The FDOF was characterized for weight, thickness, folding endurance, and dissolution using in vitro experimentations. The effect of HPMC and PEG on drug release profile and film forming properties was investigated. The prepared films exhibited satisfactory physico-chemical characteristics. Finally, it is concluded that Famotidine can be formulated with HPMC and PEG polymers to achieve oral film formulation by using solvent casting method.

Keywords: Famotidine,HPMC,PEG, innovative fast dissolving oral film dosage form.


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