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Abstract

ANTICANCER ACTIVITY OF JELLYFISH, CHRYSAORA QUINQUECIRRHA (DESOR 1848) FROM VELLAR ESTUARY, SOUTHEAST COAST OF INDIA

Suganthi Krishnan*, Perumal Pachiappan , Tufail Ahmed Mazharbasha andKeerthana Ranganathan

ABSTRACT

Background: Marine organisms are considered to be an inexhaustible
source of chemical compounds that produce a wide variety of
biologically active secondary metabolites. Scyphozoan jellyfishes have
become an important target for the biotechnology industry because of
the large number of bioactive compounds recently discovered from
them. Objective: The present investigation pertains to the evaluation
of the anticancer activity of extracts of jellyfish Chrysaora
quinquecirrha, collected from Vellar estuary, South east coast of India.
Methodology: The nematocyst extracts of tentacles of jellyfish were
characterized for protein contents and their anticancer potential was
determined on human lung cancer cell lines (A549) with 205.0 μg
GI50. Results: The study showed that the extracted peptides could be
amino acid residues (secondary amides) which might be responsible for the anticancer
potential on human lung cancer cell lines (A549). Conclusions: Marine organisms are
considered to be an inexhaustible source of chemical compounds that produce a wide variety
of biologically active secondary metabolites. Scyphozoan jellyfishes have become an
important target for the biotechnology industry because of the large number of bioactive
compounds recently discovered from them. This paper focuses on the anticancer potential of
marine species with certain pharmaceutical interest, which could confer anticancer activity.

Keywords: Anticancer, marine compounds, jellyfish, venom.


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