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*Jawad A., Intan F. S., Jiyauddin K., Asbi A. S. Budiasih, M. Kaleemullah
and Samer A. D.


A self micro-emulsifying drug delivery system (SMEDDS) has been developed to enhance diffusion rate and oral bioavailability of Flurbiprofen. The solubility of Flurbiprofen was checked in different oils, surfactants, and co-surfactants and ternary phase diagrams were constructed to evaluate the micro-emulsion domain. The Flurbiprofen SMEDDS was prepared using Capmul MCM (oil), Tween 80 (surfactant), and polyethylene glycol 400 (co-surfactant). The particle size distribution, zeta potential, and Polydispersity index were determined and found to be 12.3 nm, −0.746, and 0.138, respectively. Diffusion rate of Flurbiprofen was measured by in vitro dialysis bag method using phosphate buffer pH 6.8 as diffusion media. Developed high-performance liquid chromatography method was used to determine drug content in diffusion media. Oral bioavailability of Flurbiprofen SMEDDS was checked by using mice model. Results of diffusion rate and oral bioavailability of Flurbiprofen SMEDDS were compared with those of pure drug solution and of marketed formulation. Diffusion of Flurbiprofen SMEDDS showed maximum drug release when compared to pure drug solution and marketed formulation. The area under curve and time showed significant improvement as the values obtained were 607 ng h/mL and 1 h for SMEDDS in comparison to 445.36 and 1.36 h for market formulation suggesting significant increase (p<0.01) in oral bioavailability of Flurbiprofen SMEDDS.

Keywords: Flurbiprofen, Surfactant, Zeta Potential, Polydispersity Index and Bioavailability.

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