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Abstract

A FACET UPSHOT ON TRANSDERMAL THERAPEUTIC SYSTEMS: IN MIDDLE OF UPDATED PERSPECTIVE

*Riddhi Patel, Om Bagade, Bindiya Patel

ABSTRACT

Transdermal drug delivery (TDD) is a non-invasive route of drug administration, although its applications are limited by low skin permeability. Transdermal patch is a medicated adhesive patch that is placed on the skin to deliver the drug through the skin in order to achieve both local and systemic effect of drug at a predetermined rate over a prolonged period of time. Its main advantages includes with minimum side effects, improved bioavailability, bypass first pass metabolism and many more. The main challenge is in the design of a polymer matrix, followed by optimization of the drug loaded matrix not only in terms of release properties, but also with respect to its adhesion–cohesion balance, physicochemical properties, and compatibility and stability with other components of the system as well as with skin. The low permeability of the skin relative to other biological tissues is well known and keeps the skin as a minor port of entry for drugs. The skin is a very effective barrier for the permeation of most xenobiotics. It is rare that the industry produces a new chemical entity specific for dermal or transdermal use and often, therefore, its inherent physicochemical properties are not ideally suited to uptake into and through the skin. This means that considerable effort has to be expended on the appropriate design of a formulation or a device to deliver enough of the medicine such that there is sufficient present at its site.

Keywords: Transdermal patch, xenobiotics, bioavailability, controlled release.


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