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Abstract

PRODRUGS: A REVIEW

Shaifali Dubey*, Vandana Valecha

ABSTRACT

Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert the desired pharmacological effect. This approach has several advantages over conventional drug administration. Prodrugs are with altered physicochemical, biopharmaceutical or pharmacokinetic properties of drugs so the efficiency of drugs gets improved with specific target delivery. This article includes classification, effect of prodrug on solubility, chemical stability, bioavailability, long duration of action and site targeted challenge with examples of prodrug illustrating the role of produg as a better way for the more effective treatment of different diseases.

Keywords: Biopharmaceutical, Bioreversible, Physicochemical, Prodrug.


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