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Abstract

ROLE OF CURCUMIN AS AN ADJUVANT IN CHMEORADIOTHERPAY IN HEAD AND NECK CANCER: A RANDOMIZED TRIAL

S. Sudarsini*, Dr K.Velavan, Dr. Fahad I. Al-Saikhan

ABSTRACT

The purpose of this randomized study was to assess the efficacy and tolerability of curcumin as an adjuvant and its effects on chemo- radiotherapy in terms of tolerance and local control in the management of head and neck cancer. A study protocol was designed as per ICH guidelines and eighty histologically proved patients of head and neck cancer were selectively randomized into four arms (two study arms and two control arms). Group I (study arm) received 6600 cGy external radiation in conventional fractionation along with curcumin 1gm and group II (study arm) was treated with 6600 cGy external radiation and chemotherapy along with curcumin. One control arm (group III) was treated with 6600 cGy external radiation alone in conventional fractionation schedule. Other control arm (group IV) was treated with chemotherapy with 6600 cGy external radiation therapy in conventional fractionate schedule. The study result shows that patients were well matched in both the treatment groups(I & II). Chemo radiation tolerance was found more satisfactory with less sever acute chemo radiation toxicity in study arm patients. No patient with curcumin adjuvant therapy developed grade 3 acute radiation toxicity as encountered in control arm, 20 out of 72 patients (27%). A better quality of life during therapy was demonstrated in study arm patients with enhanced subjective response and improved Karnofsky performance status. However, overall response rate was not affected by curcumin chemo radiation therapy. It is concluded that Curcumin is well tolerated in head & neck cancer patients. It enhances the radiation tolerance, reduces accompanying acute radiation and chemo toxicity, and improves performance status and quality of life.

Keywords: Head and neck cancer; Curcumin; Quality of life; Chemo radio therapy.


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