WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

STUDY OF CROSS-LINKED SODIUM RBOXYMETHYLCELLULOSE (NACMC) AS AN ALTERNATIVE SUPERDISINTEGRANT IN FAST DISSOLVING FORMULATION.

A. S. Kulkarni, S. H. Majumdar, N. H. Aloorkar, K. M. Karande, Dada D. Kodalkar*

ABSTRACT

The present study was aimed towards the formulation and evaluation of Fast dissolution tablets of The ophylline using Cross-linked Sodium carboxymethylcellulose. Fast disintegrating tablets of Theophylline was prepared using three different super disintegrants Namely crospovidone, cross-linked sodium carboxymethylcellulose,and Non cross-linked sodium carboxy methylcellulose, and with three concentrations (2%, 3% and 5%) were prepared by direct compression method. The final blend of the drug and excipients were evaluated for powder flow properties, bulk density, tapped density and compressibility index. All the formulations were evaluated for weight variation, thickness, disintegration time,hardness, friability, wetting time and water absorption ratio. Formulation F3 showed thelow est disintegration time. In vitro dissolution studies revealed that formulation F3 showed96.36 % percent drug release at the end of 30 minutes. These results revealed that the formulation F9 containing. Cross-linked sodium carboxymethylcellulose (5%)as super disintegrant was better one which satisfied all the criteria as a Fast Disintegrating tablets.

Keywords: Fast Disintegrant tablet, Cross-linked sodium carboxymethylcellulose, bronchial asthma and chronic obstructive pulmonary disease.Fast Disintegrant tablet, Cross-linked sodium carboxymethylcellulose, bronchial asthma and chronic obstructive pulmonary disea


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More