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Abstract

DESIGN AND DEVELOPMENT OF TRIGONELLA FOENUM GRACEUM SEED POLYSACHARIDE MUCILAGE BASED MATRIX TABLETS OF DICLOFENAC SODIUM

Indranil Kumar Yadav*, and D.A. Jain

Institute of Pharmaceutical Sciences and Research Center, Bhagwant University, Ajmer- 305004, India.

ABSTRACT

In the present study, Polysaccharide mucilage derived from the seeds of fenugreek, Trigonella foenum-graceum L (family Leguminosae) was investigated as sustained release matrix forming material in Diclofenac sodium tablet formulations. Mucilage extracted from fenugreek seeds were subjected to physicochemical characterization. Matrix tablets were prepared by wet granulation technique using isopropyl alcohol as a granulating agent. Sustained release matrix tablets of diclofenac sodium, were developed by using different drug: polymer ratios.Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution using paddle method, and swelling behavior. All the formulations showed compliance with pharmacopoeial standards. Tablets prepared with Hydroxypropylmethylcellulose (HPMC 50cps) and Xanthan gum as matrix forming material for the comparative study. The dissolution study proved that the seeds mucilage of fenugreek can be used as a matrix forming material for making once daily Sustained release matrix tablets of Diclofenac sodium. The optimized formulation of fenugreek mucilage based matrix tablets (BF3) was subjected to stability studies as per ICH guidelines for three months at 45 temperature with RH 755%, and showed stability with respect to release pattern. It is concluded that the selected formulation exhibited satisfactory drug release and could extend the release up to 12 hours.

Keywords: Matrix tablets; Sustained release; Diclofenac sodium; Trigonella foenumgraceum.


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