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Abstract

SYNTHESIS AND EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF SOME 1,3,4-OXADIAZOLES,1,2,4-TRIAZOLES POSSESSING s-TRIAZOLE MOIETY

*D.Kumudha, T.Kalavathi, R.Venkatanarayanan, R.R.Reddy

ABSTRACT

Starting from substituted benzohydrazides, 2-(3-mercapto-5- substituted phenyl-4H-1,2,4-triazol-4-yl) acetohydrazide[6a-d] were prepared. From [6a-d], a series of new 1,3,4-oxadiazoles [9a-d], 1,2,4- triazoles [10a1-a2 – 10d1-d2] were synthesized and evaluated for anticonvulsant, CNS depressant activity and Neurotoxicity.

Keywords: 1, 3, 4-oxadiazole, 1, 2, 4-Triazole, Anticonvulsant, CNS depressant activity, Neurotoxicity


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