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Abstract

VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MELOXICAM AND AMOXICILLIN SODIUM IN BULK AND COMBINED DOSAGE FORM

Nazia sultana Shaik *, Shanta Kumari Katakam

ABSTRACT

A new simple, precise, accurate and selective RP-HPLC method has been developed and validated for simultaneous estimation of Meloxicam (MEL) and Amoxicillin sodium (AMXS) in injectable dosage form. The method was carried out on a C8 (250 mm × 4.6 mm i.d., 5μm) column with a mobile phase consisting of Phosphate Buffer, Acetonitrile and Methanol in the ratio of (45:10:45v/v/v) and flow rate of 1.5 ml/ min. The detection was carried out at 233nm.The retention time for MEL and AMXS were found to be 7.548 and 4.837 min respectively. The MEL and AMXS followed linearity in concentration range of 1-7μg/mL and 20-150μg/mL respectively with r²=0.9990.The amount of both drugs estimated by the proposed method was found to be in good agreement with labelled claim. The developed method was validated for precision, accuracy, sensitivity, robustness and ruggedness. The developed method can be used for routine analysis of titled drugs in combined dosage form.

Keywords: Meloxicam, Amoxicillin sodium; RP-HPLC, Validation, C-8 column


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