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Abstract

REVERSE PHASE HIGH PERFORMANCE AND HPTLC METHODS FOR THE DETERMINATION OF RILPIRIVINE BULK AND IN TABLET DOSAGE FORM

T. Sudha *, P.Shanmugasundram

*Department of Pharmaceutical Analysis, The Erode College of Pharmacy& Research Institute, Erode.
Department of Pharmaceutical chemistry, The Erode College of Pharmacy& Research Institute, Erode-638112.

ABSTRACT

Two simple, rapid, sensitive and economic chromatographic methods have been developed for the determination of Rilpirivine. First method depends on reverse phase high performance liquid chromatography. The mobile used consists of using mixed phosphate buffer: acetonitrile (60:40%v/v) with pH 6.8 and flow rate of 1.0ml/min in isocratic mode. The separation was carried out by UV detector at wavelength 272nm. A concentration range from 1-10 μg/ml was used for calibration curve. The percent recovery of rilpirivine was found to be 100.53%. Second method depends on high performance thin layer liquid chromatography. The mobile phase used consists of ethyl acetate: methanol: chloroform (8.0:1.0: 1.0%v/v/ v).Densiometric analysis was carried out at wavelength 254nm. The Rf value for rilpirivine was found to be 0.33. A concentration range from 5-30 μg/spot was used for calibration curve. The percent recovery of rilpirivine was found to be 100.17%. HPLC and HPTLC methods are widely employed in quality control assessment of drugs because of their sensitivity, repeatability and specificity. The proposed method was validated statically and recovery study for the determination of rilpirivine in bulk and in tablet dosage form was performed.

Keywords: Rilpirivine, RP-HPLC, HPTLC, validation, second generation.


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