WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PREPARATION AND IN-VITRO CHARACTERIZATION OF NEBIVOLOL TRANSDERMAL PATCHES USING SOLVENT CASTING TECHNIQUE

Jyothirmai.K , sonia. Sk, Lakshmana murthy.G*, suchitra.M, venkata swathikrishna.K3, Krantikumar.P

ABSTRACT

The aim of the present work was investigated to develop and evaluate transdermal patches of nebivolol. The transdermal patches of nebivolol were prepared by solvent casting technique. The twelve formulations of nebivolol patches were prepared ( 1:1,1:2,1:3,1:4,) different composition of HPMC K100M, HPMC K4M, Metalose SR, Glycerin, Tween 80as film former. Polyvinyl alcohol (4% w/v) was used to prepare the backing membrane. All formulations contained Tween 80 (4% v/w) as penetration enhancer and propylene glycol (40% v/w) as plasticizer in dimethyl formamide as solvent system. The prepared transdermal patches of nebivolol were evaluated for solubility determination, melting point determination, partition coefficient, permeability coefficient, Thickness, Folding Endurance, Swelling Index, Moisture Content, Moisture Uptake, Water Vapor Transmission (WVT) Study, Tensile Strength Test, In-vitro Permeation Study, Gel Strength, drug release kinetics studies, Stability Studies. The physicochemical interactions between nebivolol and different polymers were studied by Fourier Transform Infrared (FTIR). The maximum drug release in 12 h was 98.08% (F10, HPMC K4M: HPMC K100 is 1:4), which is significant (P < 0.05). Furthermore, the formulation F10 showed maximum skin permeation (13.93 mg/cm²/h) in comparison with other formulations. The mechanical properties and tensile strength revealed that the formulations were found to be strong enough but not brittle. FTIR studies did not show any evidence of interaction between the drug and the polymers. Nebivolol matrix-type transdermal therapeutic systems could be prepared with the required flux having suitable mechanical properties.

Keywords: .


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More