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Abstract

ACUTE AND SUBACUTE TOXICITY STUDIES OF THE ANTIDIABETIC POLYHERBOMINERAL FORMULATION BSL-150 IN EXPERIMENTAL ANIMAL MODELS

Vaishali R. Undale*1, Chandrashekhar D. Upasani2

1Department of Pharmacology, Seth Govind Raghunath Sable College of Pharmacy, Saswad. India.
2Department of Pharmacology, SJNB;s Shri Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Nashik, India.

ABSTRACT

A polyherbomineral formulation BSL-150 is an anitidabetic formulation manufactured by Indu Pharma and consists of combination of herbs and various bhasmas. It is used for the treatment of diabetes mellitus. The purpose of this study is to investigate the formulation for its safety and toxicity effects after oral administration in Swiss albino mice. Each tablet of BSL-150 weighing 500 mg contains Gymnema sylvestere, Tinospora cardiofolia, Embellica officinalis and various bhasmas. In an acute toxicity study the BSL 150 suspended in 5% CMC was administered orally at the dose of 2000 mg/kg and were observed closely for 72 hrs with special attention for first 4 hrs. No any mortality was observed at the dose of 2000 mg /kg. In sub acute toxicity studies BSL 15o was administered orally at the dose of 250, 500, and 1000 mg /kg to animals for 28 days. Then the animals were sacrificed and various serum parameters were measured. The histopathological changes in liver, kidney, and pancreas were studied. The results of the 28 day sub acute toxicity study shows no any change in the hematological, serum parameters and histological studies. It is concluded that the BSL 150 is safe at the dose of 2000 mg/kg of oral dose per day. The results indicate the safety of the formulation in the long term treatment with the BSL 150.

Keywords: Diabetes mellitus, BSL-150, acute and sub acute toxicity.


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