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Abstract

TO STUDY THE EFFECT OF CHEMICALS STRESS DEGRADATION CONDITIONS ON LORNOXICAM IN SELF EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) FORMULATION BY HPTLC METHOD

V. V. Chopade* And P. D. Chaudhari

ABSTRACT

Presents study was carried out the effect of chemicals stress degradation conditions on lornoxicam in self emulsifying drug delivery systems (SEDDS) by using high performance thin layer chromatographic technique. The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of dichloromethane : ethyl acetate : glacial acetic acid (9.5:0.5:0.1 v/v/v/v) This system was found to give compact spots for Lornoxicam in SEDDS formulation (Rf value of 0.45). Lornoxicam SEDDS formulation was subjected to acid, alkaline, oxidation, photodegradation and dry heat treatment was given also the degraded products were well separated from the pure drug. Densitometric analysis of Lornoxicam in SEDDS formulation was carried out in the absorbance mode at 383 nm. The linear regression data for the calibration plots showed good linear relationship with r2=/0.998/ in the concentration range of 200-/600 ng/band. The method was validated for precision, accuracy, ruggedness and recovery study. The SEDDS formulation undergoes degradation under acid, alkaline, and oxidation treatment. Peaks of degraded product were resolved from the standard drug with significantly different Rf values. This indicates that the drug is susceptible to acid,/alkaline and oxidation degradation. Statistical analysis proves that the method is reproducible and selective for the estimation of sensitivity of chemical stress conditions in SEDDS formulation of lornoxicam. As the method could effectively separate the drug from its degradation products, it can be employed as stability study.

Keywords: Lornoxicam , Self Emulsifying Drug Delivery System (SEDDS) formulation HPTLC, validation, stability-indicating and degradation.


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